ATE.v/ATBPF Antibe Therapeutics Inc C$.275
Posted: Tuesday Mar 20 7:25:48AM 2018
ATE.v/ATBPF +.25 to C$.61 Sold 1/2 in the low C$.60's to get back my costs. Will hold the rest to see if Antibe can attract a big pharma partner. Lots of shares out(260million+) so at current price, market cap is around C$158million. ASSUMING they get approved in a couple of years and sell US$1 billion a year, they should get 100-140million/yr in royalties. Market cap once that happens should be in the billion dollar range or C$5 but that's a long way off and several hurdles away. We'll see how the market prices little Antibe going forward.
Posted: Tuesday Mar 20 6:23:13AM 2018
ATE.v/ATBPF C$.36 Halted yesterday and gave back some of the 52wkhi's reached last week at C$.44. But this result seems quite good. What doctor wouldn't recommend a product that is much less likely to cause long term damage and internal bleeding to a patient. 2.5% vs 42% is very significant. However we aren't at the finish line yet. They have to find a big partner who will finance a phase III study, find the optimum dosage and get approved before anyone makes any money on this drug. Company estimates another three years before full commercialization. There could be selling on the news, even though this is probably as good a result as the company could expect.
ANTIBE THERAPEUTICS ANNOUNCES SUCCESSFUL PHASE 2B GASTROINTESTINAL SAFETY STUDY FOR LEAD PAIN DRUG, ATB-346
TORONTO, CANADA — (March 20, 2018) – Antibe Therapeutics Inc. (“Antibe” or the “Company”) (TSXV: ATE, OTCQB: ATBPF) is pleased to announce that its lead drug, ATB-346, met its primary endpoint in the Phase 2B gastrointestinal (“GI”) safety study. The double-blind study was conducted in 244 healthy volunteers and was designed to demonstrate the superiority of ATB-346 in GI safety compared to naproxen, the most prescribed nonsteroidal anti-inflammatory drug (“NSAID”) in the USA. Subjects on ATB-346 exhibited an ulceration rate of 2.5% versus an ulceration rate of 42.1% for subjects on naproxen at the end of the 2-week treatment period, with a very high degree of statistical significance (p<0.001). ATB-346 was also safe and well tolerated.
Antibe’s Chief Scientific Officer, John Wallace, commented, “The successful outcome of this study is the culmination of 15+ years of scientific research, and validates Antibe’s hydrogen sulfide-releasing technology. Gastrointestinal safety has been a major global concern with NSAIDs for decades and we now have clinical data unequivocally demonstrating a solution to this unmet and serious medical problem.”
Subjects received either 250 mg of ATB-346 once-daily, a dose previously shown to be very effective in reducing osteoarthritis-associated pain, or 500 mg of naproxen twice-daily. The primary endpoint for the study was the incidence of gastric or duodenal ulcers of at least 3 mm diameter with unequivocal depth, considered the gold standard in assessing the GI safety of NSAIDs. “The number of subjects that developed ulcers while on treatment with ATB-346 was 3 (out of 118), compared to 53 (out of 126) for subjects treated with naproxen,” remarked John Wallace. “This result was achieved with an impressive level of statistical significance. In addition, the incidence of elevated liver transaminases in the ATB-346 group was consistent with our expectations and the incidence associated with commonly-prescribed NSAIDs.” The study was conducted by Topstone Research Ltd. (“Topstone”) in Toronto, Canada. A detailed summary of the clinical trial results, including secondary endpoints, will be available for release in Q2 2018.
“This extraordinary result exceeded our expectations for ATB-346,” remarked Dan Legault, Antibe’s CEO. “With human proof-of-concept GI safety data now in hand, Antibe will continue its regional licensing discussions and will now engage global pharmaceutical firms to support our objective of reaching a partnering event for the major markets. In parallel, we will conduct our placebo-controlled dose ranging and effectiveness study with a data read-out expected in Q4 2018. As well, we will accelerate development of Antibe’s other novel NSAIDs, including ATB-352, a non-addictive analgesic for the treatment of severe pain that addresses the global opioid crisis.”
Changes to the Board of Directors
The Company is pleased to announce the appointment of Amal Khouri (B.Sc., MBA) to its Board of Directors, effective immediately. Ms. Khouri brings extensive pharmaceutical business development experience to the Company and succeeded Samira Sakhia as of March 19, 2018.
“On behalf of the entire team at Antibe, I would like to extend our sincere gratitude to Samira for her invaluable contribution to the Company over the past 3 and a half years,” commented Walt Macnee, Antibe’s Chairman. “We are also delighted to welcome Ms. Khouri to the Antibe Board. Ms. Khouri has extensive experience in global partnering and licensing deals in the pharmaceutical industry. Her expertise will be a tremendous asset to our Board and shareholders as we prepare to commence global partnering discussions for our lead drug, ATB-346.”
Ms. Khouri has more than 15 years of business development experience in the pharmaceutical industry and is presently Vice President of Business Development at Knight Therapeutics Inc. (“Knight”). Prior to Knight, Ms. Khouri worked at Novartis Pharma for over 7 years, where she held multiple positions within the global business development and licensing team in Basel, Switzerland. Before joining Novartis, she worked in business development at Paladin Labs in roles with increasing responsibilities. Ms. Khouri holds a B.Sc. in Biochemistry from McGill University and an M.B.A. from the University of Ottawa.
ATB-346 is a hydrogen sulfide-releasing derivative of naproxen. NSAIDs are the most commonly used therapy for osteoarthritis, yet their use is associated with a high incidence of gastrointestinal ulceration and bleeding. NSAIDs are also widely used in a number of conditions, including rheumatoid arthritis, ankylosing spondylitis, and general pain reduction, with a similarly high rate of gastrointestinal ulceration and bleeding. It is well-accepted that patients with these conditions would benefit greatly from an effective, GI-sparing anti-inflammatory/analgesic agent such as ATB-346.
About Antibe Therapeutics Inc.
Antibe develops safer medicines for pain and inflammation. Antibe’s technology involves linking a hydrogen sulfide-releasing molecule to an existing drug to produce a patented, improved medicine. Antibe’s lead drug, ATB-346, targets the global need for a safer, non-addictive drug for chronic pain and inflammation. ATB-352, the second drug in Antibe’s pipeline, targets the urgent global need for a non-addictive analgesic for treating severe acute pain, while ATB-340 is a GI-safe derivative of aspirin. www.antibethera.com.
Antibe’s subsidiary, Citagenix Inc. (“Citagenix”), is a leader in the sales and marketing of tissue regenerative products servicing the orthopedic and dental marketplaces. Since its inception in 1997, Citagenix has become an important source of knowledge and experience for bone regeneration in the Canadian medical device industry. Citagenix is active in 15 countries, operating in Canada through its direct sales teams, and internationally via a network of distributor partnerships. www.citagenix.com.
Forward Looking Statements
This news release includes certain forward-looking statements, which may include, but are not limited to, the proposed licensing and development of drugs. Any statements contained herein that are not statements of historical facts may be deemed to be forward-looking, including those identified by the expressions "will", "anticipate", "believe", "plan", "estimate", "expect", "intend", "propose" and similar expressions. Forward-looking statements involve known and unknown risks and uncertainties that could cause actual results, performance, or achievements to differ materially from those expressed or implied in this news release. Factors that could cause actual results to differ materially from those anticipated in this news release include, but are not limited to, the Company’s inability to secure additional financing and licensing arrangements on reasonable terms, or at all, its inability to execute its business strategy and successfully compete in the market, and risks associated with drug and medical device development generally. Antibe Therapeutics Inc. assumes no obligation to update the forward-looking statements or to update the reasons why actual results could differ from those reflected in the forward-looking statements except as required by applicable law.
Antibe Therapeutics Inc.
Chief Executive Officer
Posted: Tuesday Mar 13 10:33:09AM 2018
ATE.v/ATBPF +.02 to C$.385 13 million shares traded so far today.... PR today says no material change but it's traders anticipating positive results next week from the safety trial. There will undoubtedly be selling on the news, regardless of the trial results but a positive outcome will lead to a big partner and pivotal phase III trials and eventually commercialization. Many current holders have big profits already so I anticipate some selling next week but since I am a recent buyer, I will probably hold.
Posted: Monday Mar 12 7:09:44AM 2018
ATE.v +.05 to C$.33 Antibe on the move with 1.44 million traded so far this morning. Top line results from Phase II study of damage to gastrointestinal tract for ATB-346 vs naproxen are due out sometime next week, March 19. Healthy test subjects had an endoscopy done before and after dosage with ATB-346 and naproxen(aleve). We know that naproxen does damage the GI tract. If ATB-346 can show similar pain relief WITHOUT GI tract damage, this could be a billion dollar drug. Arthritis suffers are the immediate target
Posted: Wednesday Feb 28 9:40:14AM 2018
ATE.v -.01 to C$.26 Here is an old 2017 article from Zack's reviewing Antibe and giving it a price target of C$.85. Does a good job of presenting both the positive and negative aspects of this little company and it's chances of getting ATB-346 approved.
Posted: Tuesday Feb 27 8:30:41AM 2018
Antibe Therapeutics is a small Canadian pharma working on pain relievers. They have their main drug, AT-346, in phase II trials and anticipate results in mid to late March on the safety aspects. ATB-346 is a derivative of naproxen designed to minimize stomach irritation and have minimal impact on blood pressure. Their phase II study on the gastro intestinal safety of ATB-346 is a pivotal event for this small biotech. Naproxen or Aleve has a big market share of the pain reliever market but has the negative side effect of GI irritation, like most NSAID's. In addition to GI irritation, some NSAID's had to be pulled from the market due to increasing the chances of the cardio vascular event. ATB-346 is also being tested for impact on blood pressure.
If their phase II studies are successful, Antibe will seek out partners to conduct the phase III studies and help with future commercialization.
Antibe has tripled off the bottom in late 2017 at .095 so I am not early. I just found out about it Sunday. There are 163 million shares outstanding, 21million options and 60 million warrants for a FD share count of 244million shares. At the current share price of C$.28, market cap is C$68million. If ATB-346 gets to market and fulfills the company's goals of all the pain relieving benefits of naproxen without it's main negative side effects, Antibe should be worth many times C$68million.
This is speculative and has already runup but there is still significant upside IF the trial results are very positive and Antibe can attract a bigger partner to conduct very thorough phase III trials. This pain reliever is so prevalent in the market, the FDA will want a huge study to rule out any unknown side effects and that will cost a lot of money. If the phase II is successful, I would not be surprised to see a buyout of the company.